Let's start with the simplest case. You have a line where a simple function call extends past the end of the normal boundary (79 characters per PEP 8, though I find myself trying to stay below that for historical reasons relating to specific editors, formatters and printing systems):
do_the_first_things_first(thefirstthing, thesecondthing, thelastofthethings, reasons=None)
There are many ways that would work. Here's one:
do_the_first_things_first(thefirstthing, thesecondthing, thelastofthethings, reasons=None)